YRR1/YOR162C Summary Help

Standard Name YRR1 1
Systematic Name YOR162C
Alias PDR2 2 , 3
Feature Type ORF, Verified
Description Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication (1, 4, 5, 6, 7)
Name Description Yeast Reveromycin-A Resistant 1
Chromosomal Location
ChrXV:641992 to 639560 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 89 cM
Gene Ontology Annotations All YRR1 GO evidence and references
  View Computational GO annotations for YRR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 12 genes
Regulators 5 genes
Classical genetics
gain of function
Large-scale survey
27 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 6
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Negative Genetic: 5
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 3

Expression Summary
Length (a.a.) 810
Molecular Weight (Da) 92,467
Isoelectric Point (pI) 8.17
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:641992 to 639560 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 89 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2433 641992..639560 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005688
References cited on this page View Complete Literature Guide for YRR1
1) Cui Z, et al.  (1998) Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol Microbiol 29(5):1307-15
2) Golin, J.  (1989) Personal Communication, Mortimer Map Edition 10
3) Keeven J, et al.  (2002) PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors. Curr Genet 41(1):11-9
4) Zhang X, et al.  (2001) Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J Biol Chem 276(12):8812-9
5) Le Crom S, et al.  (2002) New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol 22(8):2642-9
6) Lucau-Danila A, et al.  (2003) Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. J Biol Chem 278(52):52641-50
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
9) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87