YPT6/YLR262C Summary

YPT6 BASIC INFORMATION

Standard Name	YPT6 1
Systematic Name	YLR262C
Feature Type	ORF, Verified
Description	GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 (1, 2, 3)
Name Description	Yeast Protein Two 1

GO Annotations	All YPT6 GO evidence and references
	View Computational GO annotations for YPT6
Molecular Function
Manually curated	GTPase activity (ISS, TAS)
Biological Process
Manually curated	intracellular protein transport (IGI, TAS) retrograde transport, endosome to Golgi (IMP, TAS)
Cellular Component
Manually curated	Golgi apparatus (TAS)

Mutant Phenotype	All YPT6 Phenotype details and references
Classical genetics
null	carboxypeptidase Y (Prc1p) modification: decreased resistance to gentamycins: decreased resistance to bortezomib: increased
Large-scale survey
null	inositols excretion: increased competitive fitness: decreased heat sensitivity: increased metal resistance: decreased replicative lifespan: increased resistance to rapamycin: decreased resistance to wortmannin: normal resistance to caffeine: decreased resistance to hygromycin B: decreased resistance to monensin: decreased resistance to pyocyanin: decreased respiratory growth: decreased rate viable

Interactions	YPT6 All interactions details and references
	717 total interaction(s) for 484 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 13 Biochemical Activity: 6 PCA: 2 Reconstituted Complex: 6 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 17 Phenotypic Enhancement: 260 Phenotypic Suppression: 153 Synthetic Growth Defect: 50 Synthetic Lethality: 178 Synthetic Rescue: 5

Sequence Information

ChrXII:668893 to 668246 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..648	668893..668246	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004252

YPT6 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for YPT6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YPT6]

1)	Li B and Warner JR (1996) Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem 271(28):16813-9
2)	Lazar T, et al. (1997) Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22(12):468-72
3)	Luo Z and Gallwitz D (2003) Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments. J Biol Chem 278(2):791-9

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.