YPT1/YFL038C Summary

YPT1 BASIC INFORMATION

Standard Name	YPT1 1
Systematic Name	YFL038C
Feature Type	ORF, Verified
Description	Rab family small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) (2, 3) Also known as: YP2
Name Description	Yeast Protein Two 1

GO Annotations	All YPT1 GO evidence and references
	View Computational GO annotations for YPT1
Molecular Function
Manually curated	GTPase activity (IDA)
Biological Process
Manually curated	early endosome to Golgi transport (IMP) ER to Golgi vesicle-mediated transport (IMP) Golgi vesicle budding (IGI) protein complex assembly (IDA) protein retention in Golgi apparatus (IGI) retrograde vesicle-mediated transport, Golgi to ER (IGI, IMP) vesicle-mediated transport (IMP)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA) Golgi membrane (IDA) trans-Golgi network (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All YPT1 Phenotype details and references
Classical genetics
conditional	cold sensitivity: increased heat sensitivity: increased CPY secretion: abnormal resistance to paromomycin: decreased vegetative growth: decreased rate
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased

Interactions	YPT1 All interactions details and references
	141 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Affinity Capture-Western: 16 Biochemical Activity: 4 Co-crystal Structure: 2 Co-purification: 3 FRET: 1 PCA: 4 Reconstituted Complex: 8 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 5 Dosage Rescue: 23 Phenotypic Enhancement: 1 Phenotypic Suppression: 8 Synthetic Growth Defect: 7 Synthetic Lethality: 26 Synthetic Rescue: 6

Sequence Information

ChrVI:55985 to 55365 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -59 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..621	55985..55365	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001856

YPT1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for YPT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YPT1]

1)	Gallwitz D, et al. (1983) A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product. Nature 306(5944):704-7
2)	Miaczynska M, et al. (1997) The yeast Rab escort protein binds intracellular membranes in vivo and in vitro. J Biol Chem 272(27):16972-7
3)	Morsomme P and Riezman H (2002) The Rab GTPase Ypt1p and tethering factors couple protein sorting at the ER to vesicle targeting to the Golgi apparatus. Dev Cell 2(3):307-17

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