Standard Name	ARR1 (see Nomenclature conflict Note)
Systematic Name	YPR199C
Alias	YAP8 1 , ACR1 2
Feature Type	ORF, Verified
Description	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds (2, 3, 4)
Name Description	ARsenicals Resistance

Chromosomal Location	ChrXVI:939032 to 938148 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ARR1
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA, IMP)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance (IGI, IMP)
High-throughput	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted ARR1 Binding Site Locations
	TTAATAA 5 [Search intergenic regions for TTAATAA ]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	arsenite(3-) accumulation: increased resistance to sodium arsenate: decreased resistance to sodium metaarsenite: decreased resistance to potassium antimonyl tartrate: decreased resistance to arsenate ion: decreased resistance to sodium arsenite: decreased
overexpression	resistance to sodium arsenate: normal resistance to sodium metaarsenite: normal
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to sodium arsenite: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 PCA: 1 Two-hybrid: 43
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 4 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:939032 to 938148 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..885 939032..938148 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006403