KAR3/YPR141C Summary Help

KAR3 BASIC INFORMATION

Standard Name KAR3
Systematic Name YPR141C
Alias OSR11
Feature Type ORF, Verified
Description Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate (1, 2, 3, 4, 5)
Name Description KARyogamy
GO Annotations All KAR3 GO evidence and references
    View Computational GO annotations for KAR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All KAR3 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions KAR3 All interactions details and references
255 total interaction(s) for 154 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 14
Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 55
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 134
  • Synthetic Rescue: 7
Sequence Information
ChrXVI:817919 to 815730 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 94.4 cM
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2190 817919..815730 2004-07-21 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006345

KAR3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for KAR3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAR3]

1) Meluh PB and Rose MD  (1990) KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60(6):1029-41
2) Page BD, et al.  (1994) Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J Cell Biol 124(4):507-19
3) Middleton K and Carbon J  (1994) KAR3-encoded kinesin is a minus-end-directed motor that functions with centromere binding proteins (CBF3) on an in vitro yeast kinetochore. Proc Natl Acad Sci U S A 91(15):7212-6
4) Mackey AT and Gilbert SP  (2003) The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility. J Biol Chem 278(6):3527-35
5) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64