Standard Name	CTF4 1
Systematic Name	YPR135W
Alias	CHL15 , POB1
Feature Type	ORF, Verified
Description	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion (2, 3)
Name Description	Chromosome Transmission Fidelity 1

Chromosomal Location	ChrXVI:799234 to 802017 | ORF Map | GBrowse
	Genetic position: 103 cM

	View Computational GO annotations for CTF4
Molecular Function
Manually curated	chromatin binding (IDA) DNA binding (ISS)
Biological Process
Manually curated	DNA repair (IGI, IMP) DNA replication initiation (IMP) DNA-dependent DNA replication (IMP, IPI) double-strand break repair via break-induced replication (IMP) mitotic sister chromatid cohesion (IGI, IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	nuclear chromosome (IDA) nuclear replication fork (IDA) nucleus (IPI) replication fork protection complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased lifespan: decreased GFP-Rap1 distribution: abnormal Smc3p modification: decreased resistance to hydroxyurea: decreased resistance to benomyl: decreased resistance to Calcofluor White: decreased transposable element transposition: increased
unspecified	colony sectoring: increased
Large-scale survey
null	UV resistance: decreased bud morphology: abnormal budding index: increased cell size: increased glycogen accumulation: decreased colony sectoring: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased heat sensitivity: increased metal resistance: decreased mitotic recombination: increased Rad52-YFP distribution: increased resistance to sodium arsenite: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to formaldehyde: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to paromomycin: decreased resistance to cadmium dichloride: decreased resistance to cisplatin: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to sodium selenide: decreased resistance to sirolimus: decreased resistance to doxorubicin: decreased starvation resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	727 total interaction(s) for 358 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 2 Affinity Capture-Western: 28 Biochemical Activity: 4 Co-purification: 4 Protein-peptide: 3 Reconstituted Complex: 10 Two-hybrid: 10
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 2 Dosage Rescue: 2 Negative Genetic: 175 Phenotypic Enhancement: 8 Phenotypic Suppression: 4 Positive Genetic: 20 Synthetic Growth Defect: 286 Synthetic Lethality: 146 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:799234 to 802017 | ORF Map | GBrowse
	Genetic position: 103 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2784 799234..802017 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006339