Standard Name	SCD6 1
Systematic Name	YPR129W
Alias	LSM13
Feature Type	ORF, Verified
Description	Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress (2, 3, 4, 5)
Name Description	Suppressor of Clathrin Deficiency 2

Chromosomal Location	ChrXVI:792687 to 793736 | ORF Map | GBrowse

Molecular Function
Manually curated	eukaryotic initiation factor 4G binding (IDA) mRNA binding (IDA) RNA binding (ISS)
Biological Process
Manually curated	cytoplasmic mRNA processing body assembly (IMP) negative regulation of translational initiation (IDA, IMP) stress granule assembly (IMP)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA) cytoplasmic stress granule (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	resistance to ferrozine(2-): decreased resistance to cobalt chloride hexahydrate: decreased
overexpression	vegetative growth: decreased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased dessication resistance: decreased resistance to fluconazole: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	87 total interaction(s) for 76 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 2 Biochemical Activity: 2 PCA: 6 Reconstituted Complex: 5 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 21 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:792687 to 793736 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1050 792687..793736 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006333