SCD6/YPR129W Summary Help

Standard Name SCD6 1
Systematic Name YPR129W
Alias LSM13
Feature Type ORF, Verified
Description Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress (2, 3, 4, 5)
Name Description Suppressor of Clathrin Deficiency 2
Chromosomal Location
ChrXVI:792687 to 793736 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SCD6 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
106 total interaction(s) for 91 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 43
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • PCA: 6
  • Reconstituted Complex: 5
  • Two-hybrid: 13

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 21
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 349
Molecular Weight (Da) 39,189
Isoelectric Point (pI) 7.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:792687 to 793736 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1050 792687..793736 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006333
References cited on this page View Complete Literature Guide for SCD6
1)   personal communication
2) Nelson KK and Lemmon SK  (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32
3) Albrecht M and Lengauer T  (2004) Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett 569(1-3):18-26
4) Rajyaguru P, et al.  (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76