YPR1/YDR368W Summary Help

Standard Name YPR1 1
Systematic Name YDR368W
Feature Type ORF, Verified
Description NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Yeast Putative Reductase 6
Chromosomal Location
ChrIV:1213904 to 1214842 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YPR1 GO evidence and references
  View Computational GO annotations for YPR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
27 total interaction(s) for 24 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 12
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 312
Molecular Weight (Da) 34,755
Isoelectric Point (pI) 7.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1213904 to 1214842 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..939 1213904..1214842 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002776
References cited on this page View Complete Literature Guide for YPR1
1) Petrash JM, et al.  (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132(1-3):673-83
2) Ford G and Ellis EM  (2002) Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase. Yeast 19(12):1087-96
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Chang Q, et al.  (2007) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta 1773(3):321-9
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Nakamura K, et al.  (1997) Amino acid sequence and characterization of aldo-keto reductase from bakers' yeast. Biosci Biotechnol Biochem 61(2):375-7