Standard Name	BRR1
Systematic Name	YPR057W
Feature Type	ORF, Verified
Description	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed (1, 2, 3)
Name Description	Bad Response to Refrigeration 1

Chromosomal Location	ChrXVI:672471 to 673496 | ORF Map | GBrowse

	View Computational GO annotations for BRR1
Molecular Function
Manually curated	RNA binding (IPI)
Biological Process
Manually curated	spliceosomal complex assembly (IMP)
Cellular Component
Manually curated	small nuclear ribonucleoprotein complex (IDA)

Classical genetics
conditional	cold sensitivity: increased
null	spliceosomal snRNAs accumulation: decreased cell shape: abnormal vegetative growth: decreased
Large-scale survey
null	bud morphology: abnormal glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased resistance to mycophenolic acid: increased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: increased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to sodium selenide: decreased resistance to fluconazole: increased resistance to tunicamycin: increased sporulation: decreased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	229 total interaction(s) for 201 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 128 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 62 Synthetic Growth Defect: 12 Synthetic Lethality: 5 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:672471 to 673496 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1026 672471..673496 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006261