BRR1/YPR057W Summary Help

Standard Name BRR1 1
Systematic Name YPR057W
Feature Type ORF, Verified
Description snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed (1, 2, 3)
Name Description Bad Response to Refrigeration 1
Chromosomal Location
ChrXVI:672471 to 673496 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BRR1 GO evidence and references
  View Computational GO annotations for BRR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
repressible
Resources
230 total interaction(s) for 200 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 128
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 62
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 5
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 341
Molecular Weight (Da) 39,859
Isoelectric Point (pI) 6.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:672471 to 673496 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1026 672471..673496 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006261
References cited on this page View Complete Literature Guide for BRR1
1) Noble SM and Guthrie C  (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80
2) Noble SM and Guthrie C  (1996) Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J 15(16):4368-79
3) Liu Q, et al.  (1997) The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90(6):1013-21