SRO7/YPR032W Summary Help

Standard Name SRO7 1
Systematic Name YPR032W
Alias SNI1 , SOP1 2
Feature Type ORF, Verified
Description Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description Suppressor of rho3 1
Chromosomal Location
ChrXVI:634123 to 637224 | ORF Map | GBrowse
Gene Ontology Annotations All SRO7 GO evidence and references
  View Computational GO annotations for SRO7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
442 total interaction(s) for 300 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 16
  • Biochemical Activity: 8
  • Co-fractionation: 2
  • PCA: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 27
  • Negative Genetic: 216
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 110
  • Synthetic Growth Defect: 30
  • Synthetic Rescue: 5

Expression Summary
Length (a.a.) 1,033
Molecular Weight (Da) 114,512
Isoelectric Point (pI) 8.7
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:634123 to 637224 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3102 634123..637224 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006236
References cited on this page View Complete Literature Guide for SRO7
1) Lehman K, et al.  (1999) Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol 146(1):125-40
2) Larsson K, et al.  (1998) The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene. J Biol Chem 273(50):33610-8
3) Wadskog I, et al.  (2004) Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Mol Biol Cell 15(3):1436-44
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Grosshans BL, et al.  (2006) The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p. J Cell Biol 172(1):55-66
6) Grosshans BL and Novick P  (2008) Identification and Verification of Sro7p as an Effector of the Sec4p Rab GTPase. Methods Enzymol 438:95-108
7) Liou LC, et al.  (2014) Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (lgl), regulate cell proliferation via Rho1-Tor1 pathway. Microbiology ()