CSR2/YPR030W Summary

CSR2 BASIC INFORMATION

Standard Name	CSR2 1
Systematic Name	YPR030W
Alias	MRG19 , ART8 2
Feature Type	ORF, Verified
Description	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p (1, 3, 4)
Name Description	Chs5 Spa2 Rescue 1

GO Annotations	All CSR2 GO evidence and references
	View Computational GO annotations for CSR2
Molecular Function
Manually curated	ubiquitin protein ligase binding (IPI)
Biological Process
Manually curated	fungal-type cell wall organization (IGI) regulation of transcription from RNA polymerase II promoter (IGI, IMP) ubiquitin-dependent endocytosis (ISA)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All CSR2 Phenotype details and references
Classical genetics
null	reactive oxygen species accumulation: increased chronological lifespan: increased oxidative stress resistance: decreased superoxide dismutase activity: increased catalase activity: increased glutathione peroxidase activity: increased pseudohyphal growth: decreased replicative lifespan: increased sporulation efficiency: increased
Large-scale survey
null	resistance to amiodarone: decreased resistance to nickel sulfate: decreased viable

Interactions	CSR2 All interactions details and references
	15 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 1 Biochemical Activity: 4 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Synthetic Lethality: 3

Sequence Information

ChrXVI:627877 to 631242 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3366	627877..631242	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006234

CSR2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CSR2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSR2]

1)	Santos B and Snyder M (2000) Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation. Mol Biol Cell 11(2):435-52
2)	Lin CH, et al. (2008) Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 135(4):714-25
3)	Khanday FA, et al. (2002) Molecular characterization of MRG19 of Saccharomyces cerevisiae. Implication in the regulation of galactose and nonfermentable carbon source utilization. Eur J Biochem 269(23):5840-50
4)	Kee Y, et al. (2006) The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae. J Biol Chem 281(48):36724-31

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