YME1/YPR024W Summary Help

Standard Name YME1
Systematic Name YPR024W
Alias OSD1 , YTA11 1
Feature Type ORF, Verified
Description Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover (2, 3, 4, 5, 6)
Name Description Yeast Mitochondrial Escape 2
Chromosomal Location
ChrXVI:610481 to 612724 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YME1 GO evidence and references
  View Computational GO annotations for YME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All YME1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All YME1 Interaction evidence and references
557 total interaction(s) for 450 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 9
  • Biochemical Activity: 1
  • Co-purification: 1
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 240
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 11
  • Positive Genetic: 236
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 14
  • Synthetic Rescue: 15
Resources
Expression Summary
histogram
Resources
Protein Information All YME1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:610481 to 612724 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2244 610481..612724 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006228
References cited on this page View Complete Literature Guide for YME1
1) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
2) Thorsness PE and Fox TD  (1993) Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Genetics 134(1):21-8
3) Campbell CL and Thorsness PE  (1998) Escape of mitochondrial DNA to the nucleus in yme1 yeast is mediated by vacuolar-dependent turnover of abnormal mitochondrial compartments. J Cell Sci 111 ( Pt 16)():2455-64
4) Leonhard K, et al.  (1999) Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease. Nature 398(6725):348-51
5) Dunn CD, et al.  (2006) A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol Biol Cell 17(1):213-26
6) Schreiner B, et al.  (2012) Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Mol Biol Cell 23(22):4335-46