Standard Name	EAF3
Systematic Name	YPR023C
Feature Type	ORF, Verified
Description	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition (1, 2)
Name Description	Esa1p-Associated Factor 1

Chromosomal Location	ChrXVI:610031 to 608826 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EAF3
Molecular Function
Manually curated	histone acetyltransferase activity (IDA)
Biological Process
Manually curated	DNA repair (IDA) histone acetylation (IDA) histone deacetylation (IMP) negative regulation of antisense RNA transcription (IMP) negative regulation of transcription, DNA-dependent (IMP) regulation of DNA-dependent DNA replication initiation (IMP) regulation of transcription from RNA polymerase II promoter (IMP) transcription elongation from RNA polymerase II promoter (IGI)
Cellular Component
Manually curated	histone acetyltransferase complex (IDA) NuA4 histone acetyltransferase complex (IPI) Rpd3L complex (IDA) Rpd3S complex (IDA)

Classical genetics
null	inositol excretion: increased Ptr2p-GFP accumulation: increased
Large-scale survey
null	inositol excretion: increased competitive fitness: decreased filamentous growth: decreased haploinsufficient heat sensitivity: increased invasive growth: absent lifespan: increased mutation frequency: increased nutrient utilization: increased resistance to (S)-lactic acid: increased resistance to acetic acid: increased resistance to camptothecin: increased resistance to cycloheximide: increased resistance to mycophenolic acid: increased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to dimethyl sulfoxide: decreased resistance to ethanol: decreased toxin resistance: decreased transposable element transposition: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	511 total interaction(s) for 251 unique genes/features.
Physical Interactions	Affinity Capture-MS: 79 Affinity Capture-RNA: 4 Affinity Capture-Western: 11 Co-crystal Structure: 1 Co-purification: 2 Protein-peptide: 2 Reconstituted Complex: 3 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 6 Dosage Rescue: 1 Negative Genetic: 227 Phenotypic Enhancement: 7 Phenotypic Suppression: 2 Positive Genetic: 50 Synthetic Growth Defect: 102 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 5 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:610031 to 608826 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1206 610031..608826 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006227