TIF6/YPR016C Summary Help

Standard Name TIF6 1
Systematic Name YPR016C
Alias CDC95 2
Feature Type ORF, Verified
Description Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits (3)
Name Description Translation Initiation Factor 1
Chromosomal Location
ChrXVI:593069 to 592332 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TIF6 GO evidence and references
  View Computational GO annotations for TIF6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
reduction of function
repressible
unspecified
Resources
283 total interaction(s) for 135 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 215
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 38
  • Biochemical Activity: 1
  • PCA: 6

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 4
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 245
Molecular Weight (Da) 26,457
Isoelectric Point (pI) 4.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:593069 to 592332 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..738 593069..592332 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006220
References cited on this page View Complete Literature Guide for TIF6
1) Si K and Maitra U  (1999) The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor. Mol Cell Biol 19(2):1416-26
2) Wood LC, et al.  (1999) Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. J Biol Chem 274(17):11653-9
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27