SUT2/YPR009W Summary Help

Standard Name SUT2 1
Systematic Name YPR009W
Feature Type ORF, Verified
Description Putative transcription factor of the Zn2Cys6 family; regulates sterol uptake under anaerobic conditions along with SUT1; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; SUT2 has a paralog, SUT1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Sterol UpTake 5
Chromosomal Location
ChrXVI:576552 to 577358 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SUT2 GO evidence and references
  View Computational GO annotations for SUT2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Resources
Large-scale survey
null
overexpression
Resources
63 total interaction(s) for 52 unique genes/features.
Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 53
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 268
Molecular Weight (Da) 30,257
Isoelectric Point (pI) 9.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:576552 to 577358 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..807 576552..577358 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006213
References cited on this page View Complete Literature Guide for SUT2
1) Ness F, et al.  (2001) SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Eur J Biochem 268(6):1585-95
2) Rutzler M, et al.  (2004) SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast. Eur J Biochem 271(7):1284-91
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Blanda C and Hofken T  (2013) Regulation of mating in the budding yeast Saccharomyces cerevisiae by the zinc cluster proteins Sut1 and Sut2. Biochem Biophys Res Commun 438(1):66-70
5) Bourot S and Karst F  (1995) Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165(1):97-102
6) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66