Standard Name	HAA1 1
Systematic Name	YPR008W
Feature Type	ORF, Verified
Description	Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Homolog of Ace1 Activator 1

Chromosomal Location	ChrXVI:573018 to 575102 | ORF Map | GBrowse

	View Computational GO annotations for HAA1
Molecular Function
Manually curated	sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of transcription from RNA polymerase II promoter in response to stress (IMP) response to acid (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: stressResponse (439)
Resources	YEASTRACT | YeTFaSCo

Classical genetics
null	resistance to acetic acid: decreased resistance to propionic acid: decreased resistance to butyric acid: decreased
overexpression	acid pH resistance: increased acetic acid accumulation: decreased
Large-scale survey
null	competitive fitness: increased resistance to butyric acid: decreased resistance to propionic acid: decreased resistance to tirapazamine: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to acetic acid: decreased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	36 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 4 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 9 Phenotypic Enhancement: 2 Phenotypic Suppression: 3 Positive Genetic: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:573018 to 575102 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2085 573018..575102 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006212