YPQ2/YDR352W Summary Help

Standard Name YPQ2 1
Systematic Name YDR352W
Feature Type ORF, Verified
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter (1)
Name Description Yeast PQ-loop protein 1
Chromosomal Location
ChrIV:1181801 to 1182754 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YPQ2 GO evidence and references
  View Computational GO annotations for YPQ2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
20 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 7
  • Positive Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 317
Molecular Weight (Da) 35,179
Isoelectric Point (pI) 4.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1181801 to 1182754 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..954 1181801..1182754 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002760
References cited on this page View Complete Literature Guide for YPQ2
1) Jezegou A, et al.  (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc Natl Acad Sci U S A 109(50):E3434-43