Standard Name	YPP1 1
Systematic Name	YGR198W
Feature Type	ORF, Verified
Description	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene (1, 2, 3, 4)
Name Description	alpha-sYnuclein Protective Protein 1

Chromosomal Location	ChrVII:894693 to 897146 | ORF Map | GBrowse

	View Computational GO annotations for YPP1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	protein targeting to vacuole (IDA, IMP) receptor-mediated endocytosis (IDA) response to pheromone (IDA)
Cellular Component
Manually curated	actin cortical patch (IDA) cytosol (IDA) endosome (IDA) plasma membrane (IDA)
High-throughput	cytoplasm (IDA) plasma membrane (IDA) colocalizes_with ribosome (IDA)

Classical genetics
null	inviable
Large-scale survey
null	inviable
reduction of function	competitive fitness: increased telomere length: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	67 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 1 Phenotypic Enhancement: 32 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:894693 to 897146 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2454 894693..897146 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003430