YPP1/YGR198W Summary Help

Standard Name YPP1 1
Systematic Name YGR198W
Feature Type ORF, Verified
Description Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene (1, 2, 3, 4, 5)
Name Description alpha-sYnuclein Protective Protein 1
Chromosomal Location
ChrVII:894693 to 897146 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YPP1 GO evidence and references
  View Computational GO annotations for YPP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 15 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
reduction of function
repressible
Resources
70 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 1
  • Phenotypic Enhancement: 32
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 817
Molecular Weight (Da) 95,365
Isoelectric Point (pI) 5.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:894693 to 897146 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2454 894693..897146 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003430
References cited on this page View Complete Literature Guide for YPP1
1) Flower TR, et al.  (2007) YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation. J Cell Biol 177(6):1091-104
2) Rodriguez-Pena JM, et al.  (1998) The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Yeast 14(9):853-60
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Zhai C, et al.  (2008) Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Biochem J 415(3):455-66
5) Baird D, et al.  (2008) Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J Cell Biol 183(6):1061-74