ACM1/YPL267W Summary

ACM1 BASIC INFORMATION

Standard Name	ACM1 1
Systematic Name	YPL267W
Feature Type	ORF, Verified
Description	Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein (1, 2, 3, 4)
Name Description	APC/C[Cdh1] Modulator 1

GO Annotations	All ACM1 GO evidence and references
	View Computational GO annotations for ACM1
Molecular Function
Manually curated	ubiquitin-protein ligase inhibitor activity (IDA, IGI, IMP, IPI)
Biological Process
Manually curated	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle (IDA, IGI, IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All ACM1 Phenotype details and references
Classical genetics
null	cell cycle progression in S phase: increased duration
Large-scale survey
null	budding index: increased viable

Interactions	ACM1 All interactions details and references
	28 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 8 Biochemical Activity: 7 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Rescue: 1

Sequence Information

ChrXVI:38169 to 38798 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..630	38169..38798	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006188

ACM1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ACM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ACM1]

1)	Martinez JS, et al. (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
3)	Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46
4)	Ostapenko D, et al. (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64

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