Standard Name	GYP5
Systematic Name	YPL249C
Feature Type	ORF, Verified
Description	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	Gtpase-activating protein for Ypt Proteins 2

Chromosomal Location	ChrXVI:79353 to 76669 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GYP5
Molecular Function
Manually curated	Rab GTPase activator activity (IGI, IPI, ISS)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, IPI) vesicle-mediated transport (IGI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytosol (IDA) Golgi-associated vesicle (IDA) incipient cellular bud site (IDA) plasma membrane (IDA)
High-throughput	cellular bud neck (IDA) cellular bud tip (IDA) cytoplasm (IDA)

Large-scale survey
null	competitive fitness: decreased resistance to mefloquine: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	113 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 8 Biochemical Activity: 1 Co-fractionation: 3 Co-localization: 2 Far Western: 3 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 68
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 4 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:79353 to 76669 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2685 79353..76669 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006170