NIP7/YPL211W Summary Help

Standard Name NIP7 1
Systematic Name YPL211W
Feature Type ORF, Verified
Description Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p (1, 2, 3)
Name Description Nuclear ImPort 4
Chromosomal Location
ChrXVI:153495 to 154040 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NIP7 GO evidence and references
  View Computational GO annotations for NIP7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
repressible
Resources
183 total interaction(s) for 126 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 100
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Co-fractionation: 1
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 22
  • Synthetic Growth Defect: 30
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 181
Molecular Weight (Da) 20,381
Isoelectric Point (pI) 10.06
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:153495 to 154040 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..546 153495..154040 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006132
References cited on this page View Complete Literature Guide for NIP7
1) Zanchin NI, et al.  (1997) Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Mol Cell Biol 17(9):5001-15
2) Zanchin NI and Goldfarb DS  (1999) Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Mol Cell Biol 19(2):1518-25
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4) Coltri PP, et al.  (2007) Structural Insights into the Interaction of the Nip7 PUA Domain with Polyuridine RNA(,). Biochemistry 46(49):14177-14187