CSM4/YPL200W Summary Help

Standard Name CSM4 1
Systematic Name YPL200W
Feature Type ORF, Verified
Description Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication (1, 2, 3, 4 and see Summary Paragraph)
Name Description Chromosome Segregation in Meiosis 1
Chromosomal Location
ChrXVI:171484 to 171954 | ORF Map | GBrowse
Gene Ontology Annotations All CSM4 GO evidence and references
  View Computational GO annotations for CSM4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
14 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 3

Genetic Interactions
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 156
Molecular Weight (Da) 18,307
Isoelectric Point (pI) 5.02
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:171484 to 171954 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..471 171484..171954 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006121

CSM4 encodes a protein required for accurate chromosome segregation, and was originally identified in a whole-genome expression screen for genes required for meiosis and spore formation (1). The deletion mutant undergoes both meiotic nuclear divisions and forms spores, but exhibits mild chromosome missegregation and reduced spore viability (1). Csm4p is a tail-anchored type II membrane protein with a C-terminal segment of polypeptide that serves as an endomembrane system anchor (5).

Transcription of CSM4 in haploid cells is dependent on Adr1p, a global transcription factor that acts during glucose depletion in cooperation with Cat8p (6, 7). Since Csm4p has no known function other than in diploid sporulation, detection of ADR1-regulated CSM4 transcription in haploid cells is notable and suggests that it may also have an as yet undetermined function in haploids during glucose starvation (6, 7). CSM4 is also a putative target of Isw2p, an ATP-dependent chromatin-remodeling protein targeted to early meiotic and MATa-specific genes (8).

CSM4 has no known homologs in any other species.

Last updated: 2006-08-09 Contact SGD

References cited on this page View Complete Literature Guide for CSM4
1) Rabitsch KP, et al.  (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Conrad MN, et al.  (2008) Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell 133(7):1175-87
4) Kosaka H, et al.  (2008) Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination. PLoS Genet 4(9):e1000196
5) Burri L and Lithgow T  (2004) A complete set of SNAREs in yeast. Traffic 5(1):45-52
6) Young ET, et al.  (2003) Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol Chem 278(28):26146-58
7) Tachibana C, et al.  (2005) Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8. Mol Cell Biol 25(6):2138-46
8) Gelbart ME, et al.  (2005) Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev 19(8):942-54