Standard Name	DDC1 1
Systematic Name	YPL194W
Feature Type	ORF, Verified
Description	DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress (2, 3, 4, 5)
Name Description	DNA Damage Checkpoint 1

Chromosomal Location	ChrXVI:179277 to 181115 | ORF Map | GBrowse

	View Computational GO annotations for DDC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cell cycle checkpoint (IMP) intra-S DNA damage checkpoint (IMP) meiosis (IMP) mitotic cell cycle checkpoint (IMP) recombinational repair (IDA, IGI)
Cellular Component
Manually curated	checkpoint clamp complex (IDA) condensed nuclear chromosome (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	glutathione accumulation: increased chromosome/plasmid maintenance: abnormal colony sectoring: increased mutation frequency: increased resistance to methyl methanesulfonate: decreased resistance to 5-fluorouracil: decreased resistance to selenite(2-): decreased resistance to 4-aminofolic acid: decreased spore germination: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased gamma ray resistance: decreased mitotic recombination: increased oxidative stress resistance: decreased Rad52-YFP distribution: increased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to 5-fluorouracil: decreased resistance to tunicamycin: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to bleomycin: increased resistance to hydrogen chloride: increased resistance to acetic acid: increased resistance to 4-nitroquinoline N-oxide: decreased resistance to sodium selenide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	285 total interaction(s) for 143 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Biochemical Activity: 3 Co-fractionation: 2 Co-localization: 3 PCA: 2 Reconstituted Complex: 3 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 1 Dosage Rescue: 5 Negative Genetic: 122 Phenotypic Enhancement: 14 Phenotypic Suppression: 3 Positive Genetic: 12 Synthetic Growth Defect: 62 Synthetic Lethality: 26 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:179277 to 181115 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1839 179277..181115 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006115