Standard Name	CBC2 1
Systematic Name	YPL178W
Alias	MUD13 , SAE1 , CBP20
Feature Type	ORF, Verified
Description	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif (2, 3)
Name Description	Cap Binding Complex 1

Chromosomal Location	ChrXVI:212158 to 212784 | ORF Map | GBrowse

	View Computational GO annotations for CBC2
Molecular Function
Manually curated	RNA cap binding (IDA, ISS)
Biological Process
Manually curated	mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	commitment complex (IDA) nuclear cap binding complex (IDA)

Classical genetics
null	tellurium atom accumulation: decreased resistance to mycophenolic acid: decreased resistance to 6-azauridine: decreased
unspecified	meiotic recombination: decreased sporulation: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: increased polyphosphate accumulation: abnormal competitive fitness: decreased dessication resistance: decreased endocytosis: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to dimethyl sulfoxide: decreased resistance to doxorubicin: decreased sporulation: absent sporulation: decreased sporulation efficiency: decreased starvation resistance: decreased stress resistance: increased telomere length: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	400 total interaction(s) for 258 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 1 Affinity Capture-MS: 176 Affinity Capture-RNA: 2 Affinity Capture-Western: 17 Co-localization: 2 PCA: 2 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 106 Phenotypic Enhancement: 5 Phenotypic Suppression: 4 Positive Genetic: 24 Synthetic Growth Defect: 23 Synthetic Lethality: 22 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:212158 to 212784 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..627 212158..212784 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006099