NOP53/YPL146C Summary Help

Standard Name NOP53 1
Systematic Name YPL146C
Feature Type ORF, Verified
Description Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired (1, 2)
Name Description NucleOlar Protein 1
Chromosomal Location
ChrXVI:277529 to 276162 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NOP53 GO evidence and references
  View Computational GO annotations for NOP53
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
Resources
155 total interaction(s) for 138 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 10
  • Co-fractionation: 1
  • Co-purification: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 80

Resources
Expression Summary
histogram
Resources
Length (a.a.) 455
Molecular Weight (Da) 52,555
Isoelectric Point (pI) 10.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:277529 to 276162 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1368 277529..276162 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameRRP16
Primary SGDIDS000006067
References cited on this page View Complete Literature Guide for NOP53
1) Sydorskyy Y, et al.  (2005) Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. Biochem J 388(Pt 3):819-26
2) Granato DC, et al.  (2005) Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. FEBS J 272(17):4450-63