UME1/YPL139C Summary Help

Standard Name UME1 1
Systematic Name YPL139C
Alias WTM3 2
Feature Type ORF, Verified
Description Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description Unscheduled Meiotic gene Expression 1
Chromosomal Location
ChrXVI:291051 to 289669 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UME1 GO evidence and references
  View Computational GO annotations for UME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 31 genes
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
251 total interaction(s) for 156 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 80
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 8
  • Biochemical Activity: 5
  • PCA: 3
  • Protein-peptide: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 119
  • Positive Genetic: 27
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 460
Molecular Weight (Da) 51,021
Isoelectric Point (pI) 5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:291051 to 289669 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1383 291051..289669 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006060
References cited on this page View Complete Literature Guide for UME1
1) Strich R, et al.  (1989) Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A 86(24):10018-22
2) Pemberton LF and Blobel G  (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
3) Kurdistani SK, et al.  (2002) Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet 31(3):248-54
4) Mallory MJ and Strich R  (2003) Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. J Biol Chem 278(45):44727-34
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6