GIP3/YPL137C Summary

GIP3 BASIC INFORMATION

Standard Name	GIP3 1
Systematic Name	YPL137C
Feature Type	ORF, Verified
Description	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments (1, 2)
Name Description	Glc7 Interacting Protein 1

GO Annotations	All GIP3 GO evidence and references
	View Computational GO annotations for GIP3
Molecular Function
Manually curated	protein phosphatase 1 binding (IDA) protein phosphatase type 1 regulator activity (IMP)
Biological Process
Manually curated	chromosome segregation (IMP) regulation of phosphoprotein phosphatase activity (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) endoplasmic reticulum (IDA) mitochondrion (IDA) colocalizes_with ribosome (IDA)

Mutant Phenotype	All GIP3 Phenotype details and references
Large-scale survey
null	viable
overexpression	inviable resistance to rapamycin: decreased

Interactions	GIP3 All interactions details and references
	27 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Protein-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 10 Phenotypic Suppression: 2 Synthetic Lethality: 1

Sequence Information

ChrXVI:296646 to 292816 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3831	296646..292816	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006058

GIP3 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for GIP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GIP3]

1)	Pinsky BA, et al. (2006) Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol 26(7):2648-60
2)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307

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