ISU1/YPL135W Summary Help

ISU1 BASIC INFORMATION

Standard Name ISU1 1
Systematic Name YPL135W
Alias NUA1
Feature Type ORF, Verified
Description Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable (1, 2, 3, 4)
Name Description Iron-Sulfur cluster nifU-like protein
GO Annotations All ISU1 GO evidence and references
    View Computational GO annotations for ISU1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All ISU1 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions ISU1 All interactions details and references
26 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Co-fractionation: 2
  • Co-purification: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Sequence Information
ChrXVI:297552 to 298049 | ORF Map | GBrowse
This feature contains embedded feature(s): YPL135C-A
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..498 297552..298049 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006056

ISU1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ISU1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ISU1]

1) Schilke B, et al.  (1999) Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(18):10206-11
2) Garland SA, et al.  (1999) Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly. J Mol Biol 294(4):897-907
3) Muhlenhoff U, et al.  (2003) Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. EMBO J 22(18):4815-25
4) Ramazzotti A, et al.  (2004) Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae. FEBS Lett 557(1-3):215-20