Standard Name	OAZ1 1
Systematic Name	YPL052W
Alias	YPL052W-A 1
Feature Type	ORF, Verified
Description	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p (1, 2, 3)
Name Description	Ornithine decarboxylase AntiZyme 1

Chromosomal Location	ChrXVI:458799 to 459678 | ORF Map | GBrowse

Molecular Function
Manually curated	ornithine decarboxylase inhibitor activity (IDA)
Biological Process
Manually curated	negative regulation of translational frameshifting (IMP) regulation of proteasomal protein catabolic process (IDA)
Cellular Component
Manually curated	cytoplasm (IC)

Classical genetics
null	putrescine accumulation: increased spermidine accumulation: increased
overexpression	spermidine accumulation: decreased vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to trichothecene: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	10 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-Western: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:458799 to 459678 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-12-14
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..207 458799..459005 2011-02-03 2005-12-14 Plus 1 translational frameshift 208..208 459006..459006 2011-02-03 2005-12-14 CDS 209..880 459007..459678 2011-02-03 2005-12-14
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Plus_1_translational_frameshift (208 - 208)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005973