Standard Name	CTF19 1
Systematic Name	YPL018W
Alias	MCM18
Feature Type	ORF, Verified
Description	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 (1, 2, 3, 4)
Name Description	Chromosome Transmission Fidelity 5

Chromosomal Location	ChrXVI:517651 to 518760 | ORF Map | GBrowse

	View Computational GO annotations for CTF19
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	attachment of spindle microtubules to kinetochore (IDA, IGI, IMP) chromosome segregation (IGI, IMP) establishment of mitotic sister chromatid cohesion (IMP)
Cellular Component
Manually curated	COMA complex (IDA) condensed nuclear chromosome kinetochore (IDA, IGI) nucleus (IDA)

Classical genetics
null	cell cycle progression through the G2/M phase transition: delayed chromosome/plasmid maintenance: abnormal colony sectoring: increased Chl4p-YFP distribution: abnormal Ctf3p-YFP distribution: abnormal Iml3p-YFP distribution: abnormal resistance to bortezomib: decreased resistance to benomyl: decreased resistance to cincreasin: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased resistance to chlorpromazine: decreased
unspecified	colony sectoring: increased resistance to benomyl: decreased
Large-scale survey
null	glycogen accumulation: increased colony sectoring: increased competitive fitness: decreased haploproficient heat sensitivity: increased meiosis: abnormal mitotic recombination: increased Rad52-YFP distribution: increased resistance to St. John's Wort extract: decreased resistance to nickel sulfate: increased resistance to dimethyl sulfoxide: decreased spore germination: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	332 total interaction(s) for 193 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 1 Affinity Capture-Western: 14 Co-crystal Structure: 1 Co-fractionation: 2 Co-localization: 4 PCA: 2 Reconstituted Complex: 5 Two-hybrid: 101
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 7 Dosage Rescue: 1 Negative Genetic: 76 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 36 Synthetic Lethality: 45 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:517651 to 518760 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1110 517651..518760 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005939