IRC15/YPL017C Summary

IRC15 BASIC INFORMATION

Standard Name	IRC15 1
Systematic Name	YPL017C
Feature Type	ORF, Verified
Description	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci (1, 2, 3)
Name Description	Increased Recombination Centers 1

GO Annotations	All IRC15 GO evidence and references
	View Computational GO annotations for IRC15
Molecular Function
Manually curated	microtubule binding (IDA) S-adenosylmethionine-dependent methyltransferase activity (ISS)
Biological Process
Manually curated	attachment of spindle microtubules to kinetochore during mitosis (IMP) meiotic sister chromatid segregation (IMP) microtubule anchoring (IMP) microtubule nucleation (IDA) mitotic recombination (IMP) positive regulation of mitotic cell cycle (IMP)
Cellular Component
Manually curated	microtubule (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All IRC15 Phenotype details and references
Classical genetics
null	cell cycle progression in M phase: delayed colony sectoring: increased meiosis: abnormal resistance to bortezomib: decreased
Large-scale survey
null	chromosome/plasmid maintenance: decreased competitive fitness: decreased mitotic recombination: increased Rad52-YFP distribution: increased resistance to benomyl: decreased resistance to propan-1-ol: decreased viable

Interactions	IRC15 All interactions details and references
	22 total interaction(s) for 19 unique genes/features.
Physical Interactions	Co-purification: 1 Reconstituted Complex: 1
Genetic Interactions	Synthetic Growth Defect: 6 Synthetic Lethality: 14

Sequence Information

ChrXVI:520231 to 518732 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1500	520231..518732	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005938

IRC15 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IRC15

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IRC15]

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222
3)	Keyes BE and Burke DJ (2009) Irc15 Is a microtubule-associated protein that regulates microtubule dynamics in Saccharomyces cerevisiae. Curr Biol 19(6):472-8

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.