YPK9/YOR291W Summary Help

Standard Name YPK9 1
Systematic Name YOR291W
Feature Type ORF, Verified
Description Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome (1, 2, 3, 4)
Name Description Yeast PARK9 1
Chromosomal Location
ChrXV:861175 to 865593 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YPK9 GO evidence and references
  View Computational GO annotations for YPK9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
89 total interaction(s) for 75 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 36
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 15
  • Positive Genetic: 5
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,472
Molecular Weight (Da) 166,748
Isoelectric Point (pI) 6.06
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:861175 to 865593 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4419 861175..865593 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005817
References cited on this page View Complete Literature Guide for YPK9
1) Gitler AD, et al.  (2009) Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41(3):308-15
2) Cronin SR, et al.  (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28
3) Catty P, et al.  (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32
4) Schmidt K, et al.  (2009) Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys Res Commun 383(2):198-202