Standard Name	YPI1 1
Systematic Name	YFR003C
Feature Type	ORF, Verified
Description	Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance (1, 2, 3)
Name Description	Yeast Phosphatase Inhibitor 1

Chromosomal Location	ChrVI:153124 to 152657 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YPI1
Molecular Function
Manually curated	protein phosphatase type 1 activator activity (IGI) protein serine/threonine phosphatase inhibitor activity (IDA, IMP)
Biological Process
Manually curated	cellular ion homeostasis (IMP) glycogen metabolic process (IMP) mitotic spindle assembly checkpoint (IGI) negative regulation of phosphoprotein phosphatase activity (IDA, IMP) negative regulation of protein dephosphorylation (IDA, IMP) positive regulation of phosphoprotein phosphatase activity (IGI) regulation of protein localization to nucleus (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
overexpression	glycogen accumulation: decreased ionic stress resistance: increased
repressible	cell cycle progression in anaphase: abnormal cell cycle progression through the G2/M phase transition: delayed ionic stress resistance: decreased Glc7-mYFP distribution: abnormal Sds22-mYFP distribution: abnormal
Large-scale survey
null	haploinsufficient inviable starvation resistance: decreased vegetative growth: normal
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 3 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 10 Phenotypic Enhancement: 2 Phenotypic Suppression: 9 Positive Genetic: 2 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:153124 to 152657 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..468 153124..152657 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001899