YPI1/YFR003C Summary Help

Standard Name YPI1 1
Systematic Name YFR003C
Feature Type ORF, Verified
Description Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance (1, 2, 3)
Name Description Yeast Phosphatase Inhibitor 1
Chromosomal Location
ChrVI:153124 to 152657 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YPI1 GO evidence and references
  View Computational GO annotations for YPI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
overexpression
repressible
Large-scale survey
null
overexpression
reduction of function
unspecified
Resources
55 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 10
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 9
  • Positive Genetic: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 155
Molecular Weight (Da) 18,187
Isoelectric Point (pI) 6.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:153124 to 152657 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..468 153124..152657 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001899
References cited on this page View Complete Literature Guide for YPI1
1) Garcia-Gimeno MA, et al.  (2003) Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. J Biol Chem 278(48):47744-52
2) Bharucha JP, et al.  (2008) Ypi1, a Positive Regulator of Nuclear Protein Phosphatase Type 1 Activity in Saccharomyces cerevisiae. Mol Biol Cell 19(3):1032-45
3) Marquina M, et al.  (2012) Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin. Genetics 190(4):1355-64