NUD1/YOR373W Summary

NUD1/YOR373W Summary

Standard Name	NUD1 (see Nomenclature conflict Note)
Systematic Name	YOR373W
Feature Type	ORF, Verified
Description	Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance (1, 2)

Chromosomal Location	ChrXV:1036834 to 1039389 \| ORF Map \| GBrowse

Gene Ontology Annotations All NUD1 GO evidence and references

	View Computational GO annotations for NUD1
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	establishment of spindle localization (IGI, IMP) exit from mitosis (IMP) meiotic chromosome segregation (IMP) spindle pole body separation (IMP)
Cellular Component
Manually curated	spindle pole body (IDA)

Mutant phenotypes All NUD1 Phenotype evidence and references

Classical genetics
conditional	Spc42p distribution: abnormal Kar9p distribution: abnormal spindle morphology: abnormal sporulation efficiency: decreased
Large-scale survey
null	haploinsufficient inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All NUD1 Interaction evidence and references

	55 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 2 Affinity Capture-Western: 9 Biochemical Activity: 4 Co-localization: 3 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 6 Phenotypic Enhancement: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All NUD1 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXV:1036834 to 1039389 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2556	1036834..1039389	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000005900

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
TRM2	Nomenclature conflict	NUD1 has been used to refer to both TRM2/YKR056W, a tRNA methyltransferase, and NUD1/YOR373W, a component of the cytoskeleton.

References cited on this page View Complete Literature Guide for NUD1

1)	Adams IR and Kilmartin JV (1999) Localization of core spindle pole body (SPB) components during SPB duplication in Saccharomyces cerevisiae. J Cell Biol 145(4):809-23
2)	Hotz M, et al. (2012) Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation. Cell 148(5):958-72