NDD1/YOR372C Summary

NDD1 BASIC INFORMATION

Standard Name	NDD1 1
Systematic Name	YOR372C
Feature Type	ORF, Verified
Description	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes (1)
Name Description	Nuclear Division Defective 1

GO Annotations	All NDD1 GO evidence and references
	View Computational GO annotations for NDD1
Molecular Function
Manually curated	transcription coactivator activity (IDA, IMP)
Biological Process
Manually curated	regulation of transcription involved in G2/M-phase of mitotic cell cycle (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Regulatory Role
Binding motifs	NDD1 Transcription Factor Binding Sites and References
	CCNRAWNNGG

Mutant Phenotype	All NDD1 Phenotype details and references
Classical genetics
null	inviable
overexpression	CLB2 mRNA accumulation: increased
repressible	cell cycle progression in M phase: arrested
unspecified	cell shape: abnormal cytokinesis: decreased nuclear morphology: abnormal pseudohyphal growth: increased spindle morphology: abnormal
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased

Interactions	NDD1 All interactions details and references
	17 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 5 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Synthetic Rescue: 3

Sequence Information

ChrXV:1036469 to 1034805 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1665	1036469..1034805	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005899

NDD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NDD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NDD1]

1)	Loy CJ, et al. (1999) NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3312-27

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