DGK1/YOR311C Summary Help

Standard Name DGK1 1, 2
Systematic Name YOR311C
Alias HSD1 3
Feature Type ORF, Verified
Description Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain (1, 2, 3)
Name Description DiacylGlycerol Kinase 1, 2
Chromosomal Location
ChrXV:899928 to 899056 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DGK1 GO evidence and references
  View Computational GO annotations for DGK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 112 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
380 total interaction(s) for 222 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • PCA: 3

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 311
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 9
  • Positive Genetic: 42
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 290
Molecular Weight (Da) 32,840
Isoelectric Point (pI) 9.48
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:899928 to 899056 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..873 899928..899056 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005838
References cited on this page View Complete Literature Guide for DGK1
1) Han GS, et al.  (2008) Characterization of the Yeast DGK1-encoded CTP-dependent Diacylglycerol Kinase. J Biol Chem 283(29):20443-53
2) Han GS, et al.  (2008) An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth. J Biol Chem 283(29):20433-42
3) Kosodo Y, et al.  (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14