Standard Name	DGK1 1, 2
Systematic Name	YOR311C
Alias	HSD1 3
Feature Type	ORF, Verified
Description	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain (1, 2, 3)
Name Description	DiacylGlycerol Kinase 1, 2

Chromosomal Location	ChrXV:899928 to 899056 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for DGK1
Molecular Function
Manually curated	diacylglycerol kinase activity (IDA)
Biological Process
Manually curated	phosphatidic acid biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA) integral to membrane (ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	resistance to sirolimus: increased viable
overexpression	heat sensitivity: increased nuclear morphology: abnormal subcellular morphology: abnormal
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to dimethyl sulfoxide: decreased resistance to hydroxyurea: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to nickel dichloride: increased resistance to bleomycin: decreased resistance to nalidixic acid: increased resistance to camptothecin: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	348 total interaction(s) for 210 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 PCA: 3
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 282 Phenotypic Enhancement: 2 Phenotypic Suppression: 9 Positive Genetic: 40 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:899928 to 899056 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..873 899928..899056 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005838