Standard Name	CAF20 1
Systematic Name	YOR276W
Alias	CAF2 , CAP20 2
Feature Type	ORF, Verified
Description	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E (3, 4)
Name Description	Cap Associated Factor 1
Gene Product Alias	p20 1

Chromosomal Location	ChrXV:841333 to 841818 | ORF Map | GBrowse

	View Computational GO annotations for CAF20
Molecular Function
Manually curated	translation regulator activity (IGI, IPI)
Biological Process
Manually curated	negative regulation of translation (IGI, IMP) positive regulation of cytoplasmic mRNA processing body assembly (IMP)
Cellular Component
Manually curated	mRNA cap binding complex (IPI)

Classical genetics
null	growth in exponential phase: increased rate utilization of nitrogen source: decreased viable
overexpression	growth in exponential phase: decreased rate
Large-scale survey
null	competitive fitness: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased resistance to dimethyl sulfoxide: decreased resistance to clioquinol: decreased sporulation efficiency: decreased starvation resistance: decreased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 3 Biochemical Activity: 5 PCA: 5 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 6 Dosage Rescue: 3 Negative Genetic: 11 Phenotypic Suppression: 1 Positive Genetic: 6 Synthetic Lethality: 1 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:841333 to 841818 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..486 841333..841818 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005802