ISU2/YOR226C Summary

ISU2 BASIC INFORMATION

Standard Name	ISU2 1
Systematic Name	YOR226C
Alias	NUA2
Feature Type	ORF, Verified
Description	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable (1, 2, 3)
Name Description	Iron-Sulfur cluster nifU-like protein

GO Annotations	All ISU2 GO evidence and references
	View Computational GO annotations for ISU2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular iron ion homeostasis (IMP, ISS) iron-sulfur cluster assembly (IMP, ISS) tRNA wobble uridine modification (IGI)
Cellular Component
Manually curated	mitochondrial matrix (IDA)

Mutant Phenotype	All ISU2 Phenotype details and references
Large-scale survey
null	metal resistance: decreased viable

Interactions	ISU2 All interactions details and references
	3 total interaction(s) for 3 unique genes/features.
Physical Interactions	Protein-RNA: 1 Two-hybrid: 2

Sequence Information

ChrXV:762085 to 761615 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..471	762085..761615	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005752

ISU2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for ISU2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ISU2]

1)	Schilke B, et al. (1999) Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(18):10206-11
2)	Garland SA, et al. (1999) Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly. J Mol Biol 294(4):897-907
3)	Gerber J, et al. (2004) The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Mol Cell Biol 24(11):4848-57

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