Standard Name	MGM1 (see Nomenclature conflict Note)
Systematic Name	YOR211C
Alias	MNA1
Feature Type	ORF, Verified
Description	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy (1, 2, 3, 4, 5, 6)
Name Description	Mitochondrial Genome Maintenance

Chromosomal Location	ChrXV:741569 to 738924 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 123 cM

	View Computational GO annotations for MGM1
Molecular Function
Manually curated	GTPase activity (ISA)
Biological Process
Manually curated	cellular membrane fusion (IDA) mitochondrial fusion (IDA, IMP, IPI) mitochondrial genome maintenance (IMP) mitochondrion organization (IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) intrinsic to mitochondrial inner membrane (IDA) mitochondrial crista (IDA) mitochondrial inner boundary membrane (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mitochondrial genome maintenance: abnormal mitochondrial morphology: abnormal respiratory growth: absent toxin resistance: increased
overexpression	mitochondrial genome maintenance: decreased mitochondrial morphology: abnormal
reduction of function	mitochondrial genome maintenance: absent
Large-scale survey
null	UV resistance: decreased glycogen accumulation: decreased competitive fitness: decreased endocytosis: decreased heat sensitivity: increased metal resistance: increased mitochondrial morphology: abnormal resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to CTBT: decreased respiratory growth: absent respiratory growth: decreased rate starvation resistance: decreased stress resistance: increased toxin resistance: increased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	110 total interaction(s) for 90 unique genes/features.
Physical Interactions	Affinity Capture-Western: 7 Biochemical Activity: 2 Co-fractionation: 2 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 77 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:741569 to 738924 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 123 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2006-10-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2646 741569..738924 2011-02-03 2006-10-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005737