GEP3/YOR205C Summary

GEP3 BASIC INFORMATION

Standard Name	GEP3 1
Systematic Name	YOR205C
Alias	FMP38 2 , AIM40 3
Feature Type	ORF, Verified
Description	Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies (1, 3, 4)
Name Description	GEnetic interactors of Prohibitins 1

GO Annotations	All GEP3 GO evidence and references
	View Computational GO annotations for GEP3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	mitochondrion (IDA)

Retired Name	LRC5

Mutant Phenotype	All GEP3 Phenotype details and references
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased filamentous growth: decreased invasive growth: absent mitochondrial morphology: abnormal respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: absent viable
overexpression	resistance to rapamycin: decreased resistance to LY-83583: increased

Interactions	GEP3 All interactions details and references
	12 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Synthetic Growth Defect: 10 Synthetic Lethality: 1

Sequence Information

ChrXV:727235 to 725565 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1671	727235..725565	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005731

GEP3 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for GEP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GEP3]

1)	Osman C, et al. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
2)	Rehling, P., et al. (2004) personal communication
3)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
4)	Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54

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