Standard Name	SLK19 1
Systematic Name	YOR195W
Feature Type	ORF, Verified
Description	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate (2, 3, 4)
Name Description	Synthetic Lethal Kar3p 1

Chromosomal Location	ChrXV:712866 to 715331 | ORF Map | GBrowse

	View Computational GO annotations for SLK19
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	meiosis (IMP) mitotic spindle organization in nucleus (IGI, IMP)
Cellular Component
Manually curated	condensed nuclear chromosome kinetochore (IDA) kinetochore (IDA) spindle (IDA) spindle midzone (IDA)

Classical genetics
null	chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal Cdc14p-GFP distribution: abnormal resistance to nystatin: increased resistance to fenpropimorph: decreased resistance to ketoconazole: decreased resistance to zaragozic acid: decreased resistance to terbinafine: decreased
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased haploproficient hyperosmotic stress resistance: decreased invasive growth: absent resistance to dimethyl sulfoxide: decreased resistance to L-1,4-dithiothreitol: decreased sporulation: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	204 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Biochemical Activity: 2 PCA: 5 Two-hybrid: 32
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 1 Negative Genetic: 68 Phenotypic Enhancement: 7 Phenotypic Suppression: 6 Positive Genetic: 5 Synthetic Growth Defect: 18 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 40 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:712866 to 715331 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2466 712866..715331 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005721