ULS1/YOR191W Summary Help

Standard Name ULS1 1
Systematic Name YOR191W
Alias DIS1 2 , TID4 3 , RIS1
Feature Type ORF, Verified
Description Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 4, 5)
Name Description Ubiquitin Ligase for SUMO conjugates 1
Chromosomal Location
ChrXV:692475 to 697334 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ULS1 GO evidence and references
  View Computational GO annotations for ULS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
Resources
147 total interaction(s) for 113 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 4
  • Two-hybrid: 22

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 69
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 7
  • Positive Genetic: 8
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,619
Molecular Weight (Da) 184,404
Isoelectric Point (pI) 7.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:692475 to 697334 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4860 692475..697334 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005717
References cited on this page View Complete Literature Guide for ULS1
1) Uzunova K, et al.  (2007) Ubiquitin-dependent Proteolytic Control of SUMO Conjugates. J Biol Chem 282(47):34167-75
2) Zhang Z and Buchman AR  (1997) Identification of a member of a DNA-dependent ATPase family that causes interference with silencing. Mol Cell Biol 17(9):5461-72
3) Dresser ME, et al.  (1997) DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway. Genetics 147(2):533-44
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Lescasse R, et al.  (2013) End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1. EMBO J 32(6):805-15