Standard Name	ULS1 1
Systematic Name	YOR191W
Alias	DIS1 2 , TID4 3 , RIS1
Feature Type	ORF, Verified
Description	Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 4)
Name Description	Ubiquitin Ligase for SUMO conjugates 1

Chromosomal Location	ChrXV:692475 to 697334 | ORF Map | GBrowse

	View Computational GO annotations for ULS1
Molecular Function
Manually curated	DNA-dependent ATPase activity (ISS) SUMO binding (IPI)
Biological Process
Manually curated	chromatin assembly or disassembly (IGI, IMP, IPI) mating type switching (IMP)
Cellular Component
Manually curated	nucleolus (IDA) nucleus (IDA, IPI)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to camptothecin: increased resistance to cycloheximide: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to bleomycin: increased resistance to doxorubicin: decreased resistance to benzo[a]pyrene: decreased sporulation efficiency: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	143 total interaction(s) for 114 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 3 Two-hybrid: 20
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 69 Phenotypic Enhancement: 6 Phenotypic Suppression: 7 Positive Genetic: 8 Synthetic Growth Defect: 12 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:692475 to 697334 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4860 692475..697334 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005717