SWT1/YOR166C Summary

SWT1 BASIC INFORMATION

Standard Name	SWT1 1
Systematic Name	YOR166C
Feature Type	ORF, Verified
Description	RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain (1, 2, 3)
Name Description	Synthetically lethal With Trex 1

GO Annotations	All SWT1 GO evidence and references
	View Computational GO annotations for SWT1
Molecular Function
Manually curated	endoribonuclease activity (IDA, IMP)
Biological Process
Manually curated	nuclear mRNA surveillance of mRNP export (IMP) transcription, DNA-dependent (IGI, IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All SWT1 Phenotype details and references
Classical genetics
null	unspliced mutant lacZ pre-mRNA accumulation: increased splicing defective pre-mRNA reporters localization: abnormal
overexpression	poly(A+) RNA accumulation: increased SSA1 mRNA accumulation: increased inviable
Large-scale survey
null	competitive fitness: increased viable

Interactions	SWT1 All interactions details and references
	View additional details at BioGRID
	34 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-localization: 1
Genetic Interactions	Negative Genetic: 8 Phenotypic Enhancement: 2 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 16

Sequence Information

ChrXV:648503 to 647127 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1377	648503..647127	2006-01-05	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005692

SWT1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SWT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SWT1]

1)	Rother S, et al. (2006) Swt1, a novel yeast protein, functions in transcription. J Biol Chem 281(48):36518-25
2)	Bleichert F, et al. (2006) The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc Natl Acad Sci U S A 103(25):9464-9
3)	Skruzny M, et al. (2009) An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. PLoS Biol 7(1):e8

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