SUMMARY PARAGRAPH for ELG1
Elg1p is a conserved but uncharacterized homolog of the large replication factor C (RFC) subunit Rfc1p and the alternative RFC subunits Ctf18p and Rad24p (3). Elg1p forms an alternative RFC complex with the Rfc2p, Rfc3p, Rfc4p, and Rfc5p subunits of RFC that is distinct from the previously described RFC-like complexes containing Rad24p and Ctf18p (1). This alternative Elg1p-RFC complex is important for DNA replication and genome integrity (2).
Elg1p acts in concert with Ctf18p and Rad24p to enable Rad53p checkpoint kinase activation in response to replication stress (3). Genetic data indicate that the Elg1p, Ctf18p, and Rad24p RFC-like complexes work in three separate pathways important for maintaining the integrity of the genome (1). Further, Elg1p interacts physically with Pol30p and Rad27p, has a possible role in Okazaki fragment maturation, and is required for efficient S phase progression and telomere homeostasis (3).
Strains mutant in Elg1p are defective in recovery from DNA damage during S phase, display DNA replication defects, exhibit elevated levels of recombination between homologous and nonhomologous chromosomes, sister chromatids, and direct repeats, and show increased levels of chromosome loss (1, 2).
Last updated: 2004-04-15