ARP8/YOR141C Summary

ARP8/YOR141C Summary

Standard Name	ARP8 1
Systematic Name	YOR141C
Feature Type	ORF, Verified
Description	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity (1, 2, 3)
Name Description	Actin-Related Protein 1

Chromosomal Location	ChrXV:592587 to 589942 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All ARP8 GO evidence and references

	View Computational GO annotations for ARP8
Molecular Function
Manually curated	contributes_to ATP-dependent 3'-5' DNA helicase activity (IDA) mRNA binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IMP) mitotic recombination (IMP) response to DNA damage stimulus (IMP)
Cellular Component
Manually curated	Ino80 complex (IPI) nucleus (IDA)

Mutant phenotypes All ARP8 Phenotype evidence and references

Classical genetics
null	cell shape: abnormal cell size: increased gamma ray resistance: decreased Ptr2p-GFP accumulation: increased telomere length: increased
overexpression	TBSV replicon RNA (repRNA) accumulation: increased
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal cell size: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased gamma ray resistance: decreased haploinsufficient heat sensitivity: increased nutrient utilization: increased resistance to bleomycin: increased resistance to fluconazole: increased resistance to mycophenolic acid: increased resistance to doxorubicin: decreased resistance to hydroxyurea: decreased resistance to ethanol: decreased resistance to benomyl: decreased resistance to tunicamycin: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to boric acid: decreased resistance to dimethyl sulfoxide: decreased resistance to sulfanilamide: decreased resistance to L-1,4-dithiothreitol: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All ARP8 Interaction evidence and references

	680 total interaction(s) for 463 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 4 Affinity Capture-MS: 58 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Biochemical Activity: 11 Co-localization: 1 Protein-peptide: 2 Reconstituted Complex: 11
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 399 Phenotypic Enhancement: 18 Phenotypic Suppression: 3 Positive Genetic: 101 Synthetic Growth Defect: 48 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 7 Synthetic Rescue: 5
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All ARP8 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXV:592587 to 589942 | |

Note: this feature is encoded on the Crick strand.

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2646	592587..589942	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000005667

References cited on this page View Complete Literature Guide for ARP8

1)	Poch O and Winsor B (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
2)	Shen X, et al. (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4
3)	Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)