Standard Name	UBP2 1
Systematic Name	YOR124C
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity (1, 2, 3)
Name Description	UBiquitin-specific Protease 1

Chromosomal Location	ChrXV:558642 to 554824 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UBP2
Molecular Function
Manually curated	ubiquitin-specific protease activity (IDA)
Biological Process
Manually curated	protein deubiquitination (IDA) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IGI, IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IC)

Classical genetics
null	Fur4p-GFP distribution: abnormal Rsp5p ubiquitination substrates modification: abnormal resistance to 5-fluorouracil: decreased resistance to alpha factor: decreased resistance to (S)-azetidine-2-carboxylic acid: decreased
overexpression	vegetative growth: decreased
Large-scale survey
null	competitive fitness: increased dessication resistance: decreased haploinsufficient resistance to sodium arsenite: decreased resistance to sirolimus: decreased resistance to arsenite(3-): decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: increased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to caffeine: decreased sporulation efficiency: increased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	117 total interaction(s) for 80 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Biochemical Activity: 6 Reconstituted Complex: 1 Two-hybrid: 16
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 51 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:558642 to 554824 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3819 558642..554824 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005650