GCY1/YOR120W Summary Help

Standard Name GCY1 1
Systematic Name YOR120W
Feature Type ORF, Verified
Description Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Also known as: GCY
Name Description Galactose-inducible Crystallin-like Yeast protein 8
Chromosomal Location
ChrXV:551114 to 552052 | ORF Map | GBrowse
Gene Ontology Annotations All GCY1 GO evidence and references
  View Computational GO annotations for GCY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 8 genes
Classical genetics
Large-scale survey
33 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • PCA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 17
  • Phenotypic Enhancement: 1
  • Positive Genetic: 4
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 312
Molecular Weight (Da) 35,079
Isoelectric Point (pI) 8.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:551114 to 552052 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..939 551114..552052 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005646
References cited on this page View Complete Literature Guide for GCY1
1) Norbeck J and Blomberg A  (1997) Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway. J Biol Chem 272(9):5544-54
2) Costenoble R, et al.  (2000) Microaerobic glycerol formation in Saccharomyces cerevisiae. Yeast 16(16):1483-95
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Chang Q, et al.  (2007) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta 1773(3):321-9
5) Tsvetanova NG, et al.  (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Jung JY, et al.  (2012) Characterization of GCY1 in Saccharomyces cerevisiae by metabolic profiling. J Appl Microbiol 113(6):1468-78
8) Angermayr M and Bandlow W  (2003) Permanent nucleosome exclusion from the Gal4p-inducible yeast GCY1 promoter. J Biol Chem 278(13):11026-31