PTC5/YOR090C Summary Help

Standard Name PTC5 1
Systematic Name YOR090C
Alias PPP1 2
Feature Type ORF, Verified
Description Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p (1, 2, 3, 4, 5)
Name Description Phosphatase Two C 1
Chromosomal Location
ChrXV:492841 to 491123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PTC5 GO evidence and references
  View Computational GO annotations for PTC5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 44 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 4
  • Co-fractionation: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 6
  • Negative Genetic: 7
  • Positive Genetic: 9
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 572
Molecular Weight (Da) 63,668
Isoelectric Point (pI) 9.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:492841 to 491123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1719 492841..491123 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005616
References cited on this page View Complete Literature Guide for PTC5
1) Cheng A, et al.  (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57
2) Krause-Buchholz U, et al.  (2006) YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. FEBS Lett 580(11):2553-60
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Gey U, et al.  (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem 283(15):9759-67
5) Voegtle FN, et al.  (2012) Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics 11(12):1840-52