UFE1/YOR075W Summary

UFE1 BASIC INFORMATION

Standard Name	UFE1
Systematic Name	YOR075W
Feature Type	ORF, Verified
Description	t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER (1, 2, 3) Also known as: YOR29-26
Name Description	Unknown Function Essential 1

GO Annotations	All UFE1 GO evidence and references
	View Computational GO annotations for UFE1
Molecular Function
Manually curated	SNAP receptor activity (TAS)
Biological Process
Manually curated	retrograde vesicle-mediated transport, Golgi to ER (TAS) vesicle fusion (TAS)
Cellular Component
Manually curated	endoplasmic reticulum membrane (TAS)

Mutant Phenotype	All UFE1 Phenotype details and references
Large-scale survey
null	inviable resistance to rapamycin: decreased resistance to wortmannin: normal

Interactions	UFE1 All interactions details and references
	51 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-Western: 17 Biochemical Activity: 2 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 7 Phenotypic Enhancement: 1 Synthetic Lethality: 3 Synthetic Rescue: 1

Sequence Information

ChrXV:468214 to 469254 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1041	468214..469254	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005601

UFE1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for UFE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UFE1]

1)	Downing TA and Storms RK (1996) Molecular analysis of UFE1, a Saccharomyces cerevisiae gene essential for spore formation and vegetative growth. Curr Genet 30(5):396-403
2)	Patel SK, et al. (1998) Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion. Cell 92(5):611-20
3)	Kraynack BA, et al. (2005) Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell 16(9):3963-77

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