Standard Name	SGO1 1
Systematic Name	YOR073W
Alias	YOR29-24
Feature Type	ORF, Verified
Description	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability (1, 2)
Name Description	ShuGOshin (Japanese for "guardian spirit") 1

Chromosomal Location	ChrXV:464771 to 466543 | ORF Map | GBrowse

	View Computational GO annotations for SGO1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	maintenance of meiotic sister chromatid cohesion (IMP) meiotic sister chromatid segregation (IMP) meiotic sister chromatid separation (IMP) mitotic sister chromatid segregation (IGI, IMP) mitotic spindle assembly checkpoint (IGI, IMP) positive regulation of maintenance of meiotic sister chromatid cohesion (IGI, IMP) sister chromatid biorientation (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome kinetochore (IDA) condensed nuclear chromosome, centromeric region (IDA)
High-throughput	nucleus (IDA) colocalizes_with spindle pole body (IDA)

Classical genetics
null	chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal viable
Large-scale survey
null	cell size: increased competitive fitness: decreased heat sensitivity: increased metal resistance: increased mitochondrial morphology: abnormal Rad52-YFP distribution: increased resistance to benomyl: decreased resistance to oleate: decreased resistance to wortmannin: decreased resistance to sodium arsenite: decreased resistance to hydroxyurea: decreased respiratory growth: decreased rate starvation resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	121 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 PCA: 2 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 7 Negative Genetic: 39 Phenotypic Enhancement: 3 Phenotypic Suppression: 7 Positive Genetic: 18 Synthetic Growth Defect: 14 Synthetic Lethality: 12 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:464771 to 466543 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1773 464771..466543 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005599